Northeast Ohio Medical University, CEL-SCI produce new investigational breast cancer vaccine

In partnership with CEL-SCI Corporation, Northeast Ohio Medical University (NEOMED) has produced a new investigational breast cancer vaccine. In animal tests the J-HER vaccine has shown reduction of HER-2/neu expressing breast cancer tumors, reduction mass, absence of tumor in lymph nodes or peritoneal membranes, and changes in angiogenesis.

Dr. Rosenthal, Sarah Stone and Robin Edmonds from NEOMED worked with CEL-SCI’s Dr. Daniel Zimmerman to design and test the LEAPS (Ligand Epitope Antigen Presentation System) technology vaccine. 

Present in most human breast tumor cells, the HER-2/neu protein is the target for different types of immunotherapy with sales of many billions of dollars.  Blocking this receptor protein with an antibody causes the tumor cells to commit suicide, or apoptosis. The J-HER vaccine activates a T lymphocyte response targeted to this protein that promotes killing and control of the tumor cell. In these studies, mice were immunized with the vaccine before, or one week after implantation of HER-2/neu breast cancer cells. In both cases the immune response initiated by the immunization significantly blocked further development and progression of tumors in most of the animals.

More details on the vaccine and technology available here.

NEOMED is located in Rootstown, Ohio. CEL-SCI has operations in Vienna, Virginia, and Baltimore, Maryland.

Recent Posts

Blog Post Archive

Blog Post Categories

Search the Blog

Newsticker


BioOhio Member Mark BioOhio Member

Regulatory and Quality Solutions to open new office in Boston, hire 30 | Boston Business Journal, August 28, 2014

AtriCure pushing the envelope to capture more share of $25B market, interview with Mike Carrel, CEO | Journal-News, August 28, 2014

AtriCure boosts Mason’s bioscience corridor, new HQ groundbreaking | Cincinnati.com, August 27, 2014

Summa Health System project Strong Start Ohio aims to help high-risk pregnant women | Hudson Hub Times, August 27, 2014

Ohio Academy of Science and Believe in Ohio announce new roadmap for STEM education in Ohio | Logan Daily, August 27, 2014

Young designers showing the way in adaptive design at Design Central | Plastics News, August 27, 2014

AtriCure breaks ground for new HQ in Mason | WVXU 91.7 Cincinnati, August 26, 2014

Patheon approved to manufacture GHB in Cincinnati | OutSourcingPharma.com, August 26, 2014

Dayton Children’s Hospital breaks ground on the new 260,000-square-foot patient tower | Dayton Children's Hospital, August 26, 2014

Sparton Corporation announces the grand opening of its Plymouth, MN Design Center | Business Wire, August 26, 2014

Cincinnati Children’s Hospital pilot project could help thousands of kids obtain medical services | Cincinnati Business Courier, August 25, 2014

National Science Foundation awards three Kent State University research groups a total of $1.2M | Crains Cleveland Business, August 25, 2014

Ohio University’s Heritage College of Osteopathic Medicine now open in Dublin, OH | Athens News, August 24, 2014

STERIS to make 100 new hires in Birmingham, AL, offer $40k average salaries | AL.com, August 22, 2014

Sen. Sherrod Brown to introduce legislation investigating Ohio’s surging infant death rate | Cincinnati Business Journal, August 22, 2014

STERIS Corporation buys U.S. Pipe building to expand in Birmingham, AL | WBRC6 Birmingham AL, August 20, 2014

Case Western Reserve University hosts cancer stem cell conference | WKSU Kent University, August 20, 2014

Sinus infection test invented by Ohio State University and Nationwide Children’s Hospital could curb antibiotic overuse | Columbus Business First, August 20, 2014

HealthSpot and CareSource team to improve access to healthcare | BusinessWire, August 20, 2014

EnvisionRxOptions named to Inc. Magazine’s The Inc. 500|5000″ list of America’s fastest-growing companies for second consecutive year | Herald Online, August 20, 2014