For bioscience organizations and researchers in the medical device and pharmaceutical fields, working in bioscience is more than just a job, it’s delivering a direct benefit to the lives of patients. Ohioans are curing debilitating pediatric diseases, creating less invasive surgical tools, programming highly accurate diagnostic imaging techniques, improving provider processes to reduce patient costs, personalizing medication delivery for individual patients, and much more.
This page is intended to educate the community about the value of health-related bioscience research with videos that have an Ohio connection.
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Stroke Survivors and the Path to Recovery
Stroke is the leading cause of serious disability in the world. These five stroke survivors have volunteered to share their emotional stories. Listen as they describe their symptoms, their decision to participate in a clinical trial for stroke, and their path to recovery. Neurologists in the field of stroke also add their insights. For more information about stroke, please visit: stroke.org. For more information about MultiStem, please visit athersys.com.
Sharon Thomas, a stroke survivor from Oregon, shares her emotional story about her stroke and the symptoms she experienced. Sharon participated in a clinical trial for an investigational stroke therapy, and she shares her journey to recovery.
Tedy Bruschi, former New England Patriots linebacker, is a stroke survivor. Tedy explains how important it is to recognize the signs of a stroke, because it can happen to anyone. Tedy had a stroke at the age of 31. Hear what he experienced, and what modern medicine is doing to develop additional treatments for stroke.
In August, 2011 during his second year of medical school at the University of Toledo, a persistent dry cough sent Matt to his family doctor. The same day that Matt was diagnosed metastatic lung cancer, the FDA approved a new drug, crizotinib (Xalkori®, Pfizer). After a harrowing hospital stay that included Matt twice suffering cardiac arrest, crizotinib worked and by November, Matt’s cancer was in remission. Although Matt’s cancer has recurred multiple times, a combination of traditional chemotherapy, radiation treatments, and enrollment in two clinical trials have kept his cancer controlled. Matt is currently a Ph.D. candidate at Case Western Reserve University.
Imagine doctors being able to scan your DNA from a biopsy and pinpoint the medicine that will work best for you. It’s a high-tech approach that scientists at The Ohio State Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute are already using, particularly when it comes to lung cancer, the deadliest form of the cancer in the U.S. Ray Thomas received this treatment after being diagnosed with Stage IV lung cancer.
Bill shares his experience receiving care for advanced stage lung cancer at the Cleveland Clinic. He is beating the odds with the help of his incredible multidisciplinary team using immunotherapy.
Cleveland FES Center
I AM HUMAN is a documentary that explores what it means to be human by following the incredible journeys of three people with implantable brain interfaces. The film prominently features Clevelander Bill Kochevar and the cutting-edge work of BioOhio member Cleveland Functional Electrical Stimulation (FES) Center at the Louis Stokes Cleveland VA Medical Center, Case Western Reserve University and University Hospitals Cleveland Medical Center (UH).
Shortly after his freshman year of college while on summer vacation, an ill-fated dive into a wave rendered Ian a quadriplegic. Nearly six years after being paralyzed from his chest down, Ian Burkhart has regained control of his right hand and fingers with the help of a computer chip implanted in his brain and other technology that bypass his spinal injury. The breakthrough was made possible by a cutting-edge technology called Neurobridge developed by researchers at Battelle, working with doctors at Ohio State.
With a cancer diagnosis, one usually expects to undergo surgery, chemotherapy, or some combination of the two. For Mark DuMoulin, the surgery to remove his tumor had an added complication; it took a large portion of his femur bone (21cm) with it. Mark’s surgeons reconstructed his femur bone using pieces of his healthy bone to fill in the defect, but Mark still had a leg length discrepancy of about 2 inches. Using a NuVasive device, Mark was able to regrow his own bone and reach his height.
The McInturff Family
The McInturff family had not one child, but two with cerebral palsy – Gabe, 15, and Josie, 4. The Inclusioneers, the biomedical engineering design team and a cooperative between The University of Akron and The Summit County Developmental Disabilities Board, created a tandem wheelchair for the siblings.
Ulcerative colitis patient Megan Starshak shares her story. Enable Injections has designed the enFuse on-body infusor with the patient in mind, based on the belief that enabling at home self-administration with the right wearable infusion technology can help patients can get their lives back.
Click here to watch Megan’s video on Vimeo.
Charles River, Hypophosphotasia (HPP)
When Evie was born, she wasn’t expected to survive due to the rare metabolic bone disease hypophosphotasia (HPP), which affects bone growth, breathing, and mobility. At the time of her birth, there was no treatment. Charles River works with the world’s leading pharmaceutical companies by providing expertise along the entire drug discovery and development continuum.
The human body contains approximately 10 pints of blood. It took more than 500 pints to help save Gina Walker due to complications with the birth of her daughter Addison, all of which were screened for safety by Abbott products. Her story inspires us to do the work we love – helping you lead a healthier, fuller life.
Eric Stitzlein with his brother-in-law (and liver donor) Adam during different stages of recovery following transplant surgery. Photo courtesy of Eric Stitzlein.
Five years ago, Eric found out he had a rare disease called Primary Sclerosing Cholangitis (PSC). PSC is a rare liver disease affecting 1 in 100,000 people. After receiving a liver donation from his brother-in-law, people like Eric now have the chance at a normal life because of advances in anti-rejection medications. Read more of Eric’s story here.
Joselin Linder is the author of The Family Gene. When Joselin Linder was in her twenties her legs suddenly started to swell. After years of misdiagnoses, doctors discovered a deadly blockage in her liver. Struggling to find an explanation for her unusual condition, Joselin compared the medical chart of her father—who had died from a mysterious disease, ten years prior—with that of an uncle who had died under similarly strange circumstances. A doctor working on her family’s case for twenty years finally confirmed that fourteen of Joselin’s relatives carried something called a private mutation—meaning that they were the first known people to experience the baffling symptoms of a brand new genetic mutation.
Alison Allen is 62 years old, a wife, mother of two grown sons and a heroin addict. Alison became one of the first patients to try Vivitrol, a once-monthly medication for the treatment of alcohol dependence as well as for the prevention of relapse to opioid dependence, following opioid detoxification. Vivitrol is the first and only non-narcotic, non-addictive, once-monthly medication approved for the treatment of opioid dependence. Vivitrol is manufactured in Ohio by Alkermes.
The film The Weight of a Mountain is about the children and families who are struggling to deal with the devastating effects of Sanfilippo Syndrome. It is also about the father of two Sanfilippo children and the CEO of Abeona Therapeutics who chose to climb a mountain to raise awareness of the disease and bring in needed funding for research.
Three-year-old Brayden Newbold’s parents brought him to Cincinnati Children’s for treatment when they noticed he wasn’t growing as expected. He was diagnosed with Laron syndrome, a growth disorder that causes small stature. Due to treatment at Cincinnati Children’s, Brayden Newbold has grown 3 1/2 inches since taking Increlex injections over the last 9 months. Brayden continues receiving treatment at Cincinnati Children’s Growth Center in the division of Endocrinology.
It is estimated that a third of the almost 800,000 Americans with cerebral palsy have hemiplegia, which results in disuse of the weaker hand in everyday life from childhood on with very few effective treatments. Contralaterally Controlled Functional Electrical Stimulation (CCFES) will assess a new therapy from the Cleveland FES Center for improving hand function in children with hemiplegic cerebral palsy.
Limb-girdle muscular dystrophy (LGMD) is a group of monogenic diseases that cause weakness and wasting of the muscles in the arms and legs. Plavi Mittal, Brad Williams and others describe what LGMD2B/MM is, who it affects, and the importance of a cure no matter what stage of disease progression a person is experiencing. Myonexus Therapeutics is developing first ever treatments for the disease.