COVID-19 Inventor Showcase: Constructing a COVID-19 Vaccine
October 20 @ 12:00 pm - 1:00 pm
The CCTS’s Optimizing Innovation, Commercialization and Entrepreneurship of Biomedical Research program, in partnership with the OSU Corporate Engagement Office and Nationwide Children’s Hospital’s Office of Technology Commercialization, is highlighting experts who are working together at an unprecedented pace to fight against COVID-19 on the front lines of innovation.
To inspire ongoing innovations and collaborations in the fight against COVID-19, the new Monthly Speaker Series aims to promote an entrepreneurial mindset among clinicians, faculty, senior leaders, students and staff of The Ohio State University and Nationwide Children’s Hospital. Since academic entrepreneurship is a team sport, the series will provide a forum for showcasing COVID-19 innovations as well as key resources in the innovation ecosystem.
October COVID-19 Inventor Showcase: Constructing a COVID-19 Vaccine
Messenger RNA (mRNA)-based vaccine is one of the leading candidates for fighting against COVID-19. In our work, we systematically investigated the untranslated regions (UTRs) of mRNAs in order to enhance antigen production. Through a comprehensive analysis and engineering of UTRs, we identified the optimal UTR sequences, termed as NASAR, which significantly enhanced the production of SARS-CoV-2 antigens. The NASAR mRNA encoding SARS-CoV-2 antigens induced strong immune responses in mice. More importantly, this novel mRNA-based platform provide broad applicability to a wide variety of therapeutic applications.