Forge Biologics
Published
05/25/2021
Location
Columbus
Job Type
Contact Name
Mandy Medve

Description

Role Description:

We are currently seeking a Senior Scientist to join the Forge Biologics team. This is an exciting opportunity to lead efforts and characterize bioprocess methods to support viral vector manufacturing. The candidate will lead downstream biomanufacturing development and support upstream development in the manufacturing of viral vector for clients at various scales ranging from 500mL to 500L. The ideal candidate will be highly skilled in technical problem-solving and bioprocessing techniques to support our growth in the Gene Therapy sector.

This position reports to the Director of Process Development and is responsible leading downstream process development activities for production of recombinant adeno-associated virus (rAAV) vectors. You will oversee and perform scalable downstream purification technologies for rAAV using depth filtration, FPLC systems, tangential flow filtration, and centrifugation. Work activities will also include compiling experimental data, writing protocols and study reports, and presenting findings to internal and external parties with minimal supervision. It is expected that you will lead and participate as part of the process development team while accomplishing the timely completion of assignments and reporting of unexpected technical issues.

Responsibilities:

  • Independently design, execute, and analyze experiments optimizing production and purification of AAV
  • Directly supervise the downstream activities of the Process Development Lab – manage experiments, equipment, inventory, and workloads
  • Execute downstream purification technologies related to rAAV purification using chromatography (affinity, ion-exchange, size exclusion, etc.) and filtration processes including microfiltration, depth filtration, tangential flow filtration, and sterile filtration
  • Compile and review experimental data with minimal oversight and author publications, protocols, or reports
  • Support large-scale manufacturing runs and ensure timely delivery of materials to internal and external partners
  • Delivering results in a high paced environment
  • Train and mentor junior laboratory technicians
  • Additional responsibilities not listed may be assigned as needed by leadership

Requirements:

  • Master’s Degree or higher in Chemistry, Chemical Engineering, Biochemistry, Biotechnology, or related and 8+ years’ experience, or PhD degree preferred, with 2+ years’ experience
  • Practical experience with FPLC is a must, ideally at both Lab and Pilot scales
  • Experience with other aspects of downstream purification (e.g. – clarification/filtration, TFF, etc.) is required
  • Experience with suspension cell culture at all scales: flasks, bench-top bioreactors, and large-scale single-use bioreactors is preferred
  • Experience with purification of vaccines or viral vectors is preferred
  • Proficiency with MS Excel, GraphPad Prism, and electronic lab notebooks is essential
  • Proficiency designing, executing, and analyzing DOE is highly desired
  • Must be self-motivating, organized and proactive
  • Strong technical aptitude including demonstrated experience in applying scientific reasoning to solve complex problems
  • Must have excellent verbal and written communication s
  • Must have demonstrated experience effectively managing multiple projects and staff
  • Ability to work hours necessary to support development and/or product transfer activities
  • Must be able to work independently, but is also a team player with strong collaborative skills

Reporting Outline:

  • This position reports to the Director of Process Development
  • Travel on an intermittent basis is required (approximately 5-10%) to support job responsibilities and commitments
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